Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

نویسندگان

  • Yasuhiro Horita
  • Takemasa Takii
  • Tetsuya Yagi
  • Kenji Ogawa
  • Nagatoshi Fujiwara
  • Emi Inagaki
  • Laurent Kremer
  • Yasuo Sato
  • Ryuji Kuroishi
  • Yoosa Lee
  • Toshiaki Makino
  • Hajime Mizukami
  • Tomohiro Hasegawa
  • Ryuji Yamamoto
  • Kikuo Onozaki
چکیده

The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 56 8  شماره 

صفحات  -

تاریخ انتشار 2012